A double Diels-Alder strategy towards the synthesis of Taxol analogues.

Stephanie Marie. Parra
TaxolRTM 1a, a very important drug used in cancer chemotherapy, has been synthesized by several groups. However these syntheses are long and there is still the need for a short and efficient route that would allow the production of this compound in larger amount. The route proposed by our group toward a simplified model compound 78 implied a double Diels-Alder strategy and started from readily available protected (L)-arabinose 118 or (D)-guluno-gamma-lactone 146. Conversion of 118...
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