Benefits and risks of neonatal bacille Calmette-Guerin (BCG) vaccination among Aboriginal infants in Canada: Assessment by Markov model

Michael Clark
Bacille Calmette-Guerin (BCG) vaccine is given to Canadian Aboriginal neonates in communities at high risk for tuberculosis (TB). However, severe reactions and deaths associated with the vaccine have been reported among infants born with immunodeficiency syndromes. A Markov model was developed to estimate the burden of TB among Canadian Aboriginal children, evaluate the effectiveness of BCG vaccination, and estimate threshold values for severe combined immunodeficiency (SCID) incidence at which a BCG program will reduce quality-adjusted...
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