Estrogen regulation of the human 5-HT1A receptor gene

Amanda M Cockburn
Altered regulation of the 5-HT1A receptor is implicated in depression. Since depression is twice as prevalent in women versus men and major hormonal events in women trigger depression, I evaluated estrogen regulation of the 5-HT1A receptor in rat RN46A raphe cells. Estrogen (100 nM) induced no change in transcriptional activity of the 5-HT1A promoter (-1515bp/ATG). A putative estrogen response element (1AERE, -433bp) was identified in human and mouse but not rat 5-HT1A promoter. At least...
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