Interferon regulatory factor-3 activation in adenovirus infection

Koralee Chaisson
Adenovirus (Ad) infection is accompanied by an early inflammatory response that is stimulated by the binding and/or entry of the Ad capsid to the cell. Several studies have linked NF-kappaB to the activation of pro-inflammatory cytokines and chemokines early in Ad infection, however, for many other viruses, another key transcription factor, Interferon Regulatory Factor 3 (IRF-3), also acts early in viral infection. We sought to determine if IRF-3 is activated upon Ad infection, and to...
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