Derivation and internal validation of a clinical prediction rule to identify patients with low risk of recurrent venous thromboembolism who can discontinue oral anticoagulants after five to seven months of treatment for unprovoked venous thromboembolism

Marisol Betancourt
Background. Whether to continue or to discontinue oral anticoagulation therapy (OAT) after 6 months of treatment to prevent recurrent or fatal events in unprovoked VTE patients is currently controversial. We sought to develop and internally validate a clinical prediction rule (CPR) to identify patients at low risk of recurrent VTE (at most 3% annual risk) for whom OAT could be safely discontinued. Methods. Univariate and multivariate analysis techniques were used to identify the best set...
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