HCV-Core over-expressed specifically in liver cells

Xin Min Dong
Hepatitis C viruses (HCV) affect 170 million patients, but only a minority of patients develop symptoms and manage to clear the virus, and the pathogenesis remains unknown. Previous studies discovered that some viral proteins may suppress HCV specific T lymphocytes, leading to lower immune responses. Although many mouse models have been tried in laboratories worldwide, none of them mimicked natural Human HCV infection with individual HCV genes in vivo. To study the immunopathogenesis of HCV...
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