Novel sulphur-linked AFGP analogues: Synthesis and evaluation of antifreeze activity

Wendy Campbell
Antifreeze Glycoproteins (AFGPs) are peptide based compounds found in various organisms. They are a subclass of Biological antifreezes which are especially important for fish that live in polar waters; they inhibit the growth of ice and are thus keys to the survival of these organisms. The mechanism by which these compounds inhibit ice growth is regarded as absorption-inhibition at the macromolecular level. However the mechanism of action on the molecular level is widely debated among...
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