Effects of neutrophils and reactive nitrogen oxide species in tumors as determined by genetic manipulation of the Mutatect mouse tumor model

Arsalan S Haqqani
Most human tumors exhibit accumulation of mutations throughout their progression. In addition, many human tumors are infiltrated with inflammatory cells, such as neutrophils and macrophages. These cells can generate potentially mutagenic species, including nitric oxide-derived species. We hypothesize that these species contribute to the accumulation of mutations in tumors. Our lab previously developed the 'Mutatect' mouse tumor model to study this hypothesis. Mutatect fibrosarcoma cells can form solid tumors in C57BL/6 mice when injected subcutaneously....
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.