Transcriptional regulation of the human 5-HT1A receptor gene: Implications in major depression and suicide

Sylvie Lemonde
Major depressive disorder (MDD) constitutes the most commonly diagnosed mental illness affecting 16% of the population. Reduction in serotonergic tone is the most widely accepted etiological hypothesis for MDD and antidepressant treatments enhance serotonin (5-hydroxytryptamine, 5-HT) neurotransmission. Negative regulation of serotonergic raphe neurons is mediated by somatodendritic 5-HT1A autoreceptors, which are increased in depressed suicides and become down-regulated before antidepressants take effect. I hypothesized that genetic variations in regulatory regions of this receptor that dictate...
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