The functional significance of cortical and adjacent amygdaloid sub-nuclei in the modulation of brain stimulation reward derived from the medial forebrain bundle

Maia Miguelez
The primary objective of my thesis is to explore the involvement of the amygdala, a neural structure underlying emotion, in the circuit underlying motivated behaviour as modelled by brain stimulation reward (BSR). In the first experiment, the functional links between the lateral hypothalamus (LH) and the amygdala were assessed using the metabolic marker, cytochrome oxidase. Following lesions of LH sites that supported BSR, we obtained a significant reduction of oxidative metabolism in the cortical sub-nuclei...
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