Amino-terminal transactivation subdomains of p53 contribute equally to p53-induced gene expression

Jennifer M Smith
The p53 tumour suppressor is mutated in over 50% of sporadic cancers. Its tumour suppressive functions arise in large part from transcriptional activation of target genes. Two adjacent regions within the transactivation domain of p53 are sufficient to support sequence-specific transactivation when fused to a heterologous DNA binding domain. It has been hypothesized that these two subdomains of p53 may contribute to the expression of distinct p53-responsive genes and regulate distinct biological pathways. In order...
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