The Role of Ldb1 in ErbB2/Neu-induced Mammary Tumorigenesis

Sarra Ahmed
The ste-20 like kinase (SLK) is a serine/threonine kinase activated downstream of Neu signaling and functions to mediate efficient migration and invasion of breast cancer cells. Previously, the LIM domain binding protein 1 (Ldb1) has been identified as a negative regulator of SLK kinase activity in MEF3T3 fibroblasts. Ldb1 is a transcriptional cofactor required for normal mouse embryonic development. In the current study we sought to assess the effect of mammary gland-specific Ldb1 deletion on...
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