The Role of the Claudin 6 Cytoplasmic Tail In Epidermal Differentiation and the Role of Cdx In Endodermal Development

Adebola Enikanolaiye
The mammalian skin provides a necessary barrier between the organism and the environment, defending against loss of water and solutes, preventing the invasion of pathogens as well as protecting against chemical and physical assault. Claudin (Cldn)-based Tight Junctions (TJs) are the main functional part of the skin barrier. In particular, Cldn6 through its cytoplasmic tail has been shown to be important for barrier function. In other to further investigate the role of the Cldn6 tail...
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