Reactive Oxygen Species (ROS) Up-regulates MMP-9 Expression Via MAPK-AP-1 Signaling Pathway in Rat Astrocytes

Elizabeth Malcomson
Ischemic stroke is characterized by a disruption of blood supply to a part of the brain tissue, which leads to a focal ischemic infarct. The expression and activity of MMP-9 is increased in ischemic stroke and is considered to be one of the main factors responsible for damages to the cerebral vasculature, resulting in compromised blood-brain barrier (BBB) integrity. However, the regulatory mechanisms of MMP-9 expression and activity are not well established in ischemic stroke....
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