The Role of Periostin in HER2/ErbB2-induced Breast Cancer

Vivian Lo
Periostin (Postn) is a secreted cell adhesion protein that shares a structural homology to the insect axon guidance protein fasciclin I (FAS1). Periostin interacts with multiple cell-surface receptors, most notably integrins, which activate signaling pathways to promote cancer cell survival, angiogenesis, invasion, and metastasis. Interestingly, periostin is frequently overexpressed in numerous human cancers, including breast, lung, colon, pancreatic, and ovarian cancer. Here, we investigated the role of periostin in HER2/ErbB2-induced mammary tumorigenesis. Although periostin is...
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