Genetic Ablation of cIAP2 Results in a Protection Against Denervation-Induced Skeletal Muscle Atrophy

Kristen S. Timusk
Skeletal muscle atrophy occurs as a secondary result from a number of conditions such as cancer cachexia, prolonged bed rest, and AIDS. Unfortunately, the cellular and molecular mechanisms behind atrophy are still poorly understood. It was recently found that the cellular inhibitors of apoptosis (cIAP1 and cIAP2) proteins play vital, yet redundant roles in the regulation of the NF-κB pathway, which is one of the most significant signalling pathways correlated with the loss of skeletal...
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