Part~A. Synthesis of optically active alpha-substituted acids. Part~B. The use of rhodium carbenoid reactions in organic synthesis.

Suresh Dhandayutham. Babu
Part A. Chapter 1. The Sharpless epoxidation product from E-4-phenyl-2-butene-1-ol and diethyl D-tartrate was converted into L-($-$)-phenylalanine in three steps. After completion of the above synthesis Sharpless published an extensive study of the synthesis of $\alpha$-amino acids via essentially the same route. Therefore the project was abandoned. Optically active 2-arylpropionic acids such as 2-phenylpropionic acid, 2-napthylpropionic acid, and 2-(4-isobutylphenyl)-propionic acid (Ibuprofen) were synthesized in two steps from Sharpless epoxidation products. Part B. Chapter 2. The...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.