The role of oocyte- and embryo-secreted factors in cumulus cell differentiation and their relationship to embryo quality and developmental competence.

Anil. Dhawan
Reproductive technologies could be markedly improved by the development of methods to evaluate oocyte and/or embryo quality in a non-invasive, quantitative manner. Previous work from this lab has shown that human embryos secrete factors that inhibit progesterone and estradiol production by granulosa cells. To determine if the presence of the progesterone-inhibitory factor (PIF) and estradiol-regulatory factor in human embryo-conditioned (HEC) media correlates with the health and developmental capacity of the embryos, an interspecies bioassay was...
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