Pathogenesis of rheumatoid arthritis: Insights into mechanisms of synovial hyperplasia and of reactive nitrogen species mediated inflammatory damage.

Jan. Brun
Synovial hyperplasia is a hallmark of rheumatoid arthritis (RA). This pathological change may be due to an increase in cell proliferation and/or a decrease in cell death (apoptosis). However, the rates at which these opposing mechanisms occur in the arthritic and control synovium, remain a subject of debate. Our objective was to address this debate using recently developed polyclonal antibodies to thymidylate synthase (TS, another potential cell proliferation marker), and activated caspase 3 and cleaved...
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