Studies on the role of interleukin-1 on prostaglandin production by human fetal membranes and decidua.

Recent studies have indicated the possible importance of cytokines in the onset of term and preterm labour. To understand this further, the effect of interleukin-1 ($\alpha$ and $\beta)$ and interleukin 6 on prostaglandin output by dispersed cells from human amnion, chorion laeve, and decidua obtained at term (38-42 weeks gestation) was examined. During the first or second 24 hours of culture, no significant effect of these interleukins on prostaglandin output was observed. The apparent refractoriness...