Quantitative aspects of cortisol feedback on the secretion of ACTH in dogs.

Wayne J. Windle
Seven male mongrel dogs of 8.3--13.1 kg. were bilaterally adrenalectomized and maintained for one week on replacement therapy, discontinued early enough to eliminate feedback effects of glucocorticoids by experiment time. Each dog, under light Nembutal anesthesia, received two stepwise primed constant infusions of cortisol (i.v.), each lasting 90 minutes. 23 venous blood samples were withdrawn for determination of plasma ACTH concentrations by adrenal cell suspension bioassay and 25 samples for plasma cortisol determination, at various...
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