Role of SodC in heme acquisition in Haemophilus ducreyi

Shahin Negari
Haemophilus ducreyi expresses outer-membrane receptors for both heme (TdhA) and hemoglobin (HgbA), but no mechanism yet has been identified for the transport of heme from the periplasm to the cytoplasm. SodC protein in H. ducreyi binds to heme in addition to exhibiting superoxide dismutase activity. We hypothesized that SodC is involved in heme uptake in H. ducreyi. An isogenic H. ducreyi sodC mutant was constructed. The generation time of the sodC mutant was increased compared...
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