Cycloaddition-based approaches to nor-taxoids and aphenes via magnesium- and indium-mediated reactions

Elizabeth Husk
Various synthetic routes were used in attempt to synthesize nortaxoids that have the potential to be more potent anti cancer reagents than TaxolRTM. In a previously established pathway to taxoid precursor 66, aldehyde 65 was difficult to purify and store. An alternative method involved preparing enol ether 79 using carbometallation and Wittig chemistry. An attempted synthesis of nortaxoid 97 used indium chemistry as a key step in its synthetic pathway. The chemical properties of aphenes...
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