High density lipoprotein intracellular metabolism in the kidney

Vasanthi Veereswaran
Experiments were undertaken to evaluate the factors that control the re-absorptive salvage of high density lipoproteins (HDL) in the kidney. HDL is readily taken up at the apical surface of polarized human proximal tubule epithelial cells (HKC-8). HKC-8 cells do not degrade HDL apolipoproteins, but instead transport and re-secrete the lipoprotein from the opposite, basolateral surface. Only ∼10% of the HDL lipids taken up are re-secreted, while ∼60% of the internalized HDL proteins are re-secreted....
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