dab-1 (DAB (Drosophila disabled) homolog)

Jonathan Pettitt & Gina Garriga
dab-1 encodes an ortholog of the cytoplasmic adaptor protein DISABLED, required for normal molting and meiotic arrest; DAB-1 is also required for EGL-17 secretion from vulval cells, and thus indirectly for normal sex myoblast (SM) migration and egg-laying; DAB-1 contains a conserved PTB domain and signals that confer localization to Golgi-proximal vesicles, and DAB-1 localizes to vesicular structures in vivo; dab-1 is expressed in ventral precursor cells, and DAB-1 prevents EGL-17 protein accumulation in them;...
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