Large-scale Genetic Exploration of Genome-wide Models: an Application to Human Cancer Metabolism

Youssef Hamadi, Claudio Angione, Hillel Kugler, Christoph Wintersteiger & Boyan Yordanov
Computational modelling of metabolic processes has proven to be a useful approach to formulate our knowledge and improve our understanding of core biochemical systems that are crucial to maintain cellular functions. Recently, it has become evident that metabolism is not only responsible for generating the required energy and controlling the abundance of metabolites within a cell, but also has an important role in and influence on cellular fate specification. Toward understanding the broader role of...
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