Transcriptome profiling of Plasmodium falciparum parasites from controlled human malaria infection studies

Regina May Ling Hoo
The transcriptional landscape of Plasmodium falciparum clinical isolates varies according to strain, mosquito bites, disease severity and clinical history. These confounding variations can be potentially overcome with single-strain parasites derived from controlled-human malaria infection (CHMI) studies. Here, we deconvolute the transcriptome complexity using CHMI-derived parasites from volunteers receiving the same PfPSZ dosage (Sanaria® PfSPZ Challenge). While we observe minimal interindividual transcriptional variation, there are clear deviations between volunteer groups receiving different PfSPZ doses and the...
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