LOWESS analysis for visualization of GEDDs

Long H. Do, William C. Mobley & Nishant Singhal
In our published finding (Do et al. 2015), we find evidence against domains of genome-wide gene dysregulation (GEDDs) in the Down syndrome mouse model and DS human iPSCs as compared to original findings from Letourneau et al. 2014. We have supplied the following script to allow other investigators to quickly visualize and compare their RNAseq gene expression datasets to search for corresponding GEDDs. The script performs a locally weighted scatterplot smoothing (LOWESS) analysis of RNAseq...
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