Caloric dose-responsive genes in blood cells differentiate the metabolic status of obese men

Doreen Gille, Nadine Zangger, Charlotte Soneson, Ueli Bütikofer, Mauro Delorenzi, Flurina Schwander, Katrin Annika Kopf, Magali Chollet, Barbara Walther, Kurt Laederach & Guy Vergères
We have investigated the postprandial transcriptional response of blood cells to increasing caloric doses of a meal challenge to test whether the dynamic response of the human organism to the ingestion of food is dependent on metabolic health. The randomized crossover study included seven normal weight and seven obese men consuming three doses (500/1000/1500 kcal) of a high-fat meal. The blood cell transcriptome was measured before and 2, 4, and 6 h after meal ingestion...
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