(2018)RodgersNeuroscience.pdf

Krista Rodgers, Jared Ahrendsen, Olivia Patsos, Frank Strnad, Joan Yonchek, Richard Traystman, Wendy Macklin & Paco Herson
Replacement of dead neurons following ischemia, either via enhanced endogenous neurogenesis or stem cell therapy, has long been sought. Unfortunately, while various therapies that enhance neurogenesis or stem cell therapies have proven beneficial in animal models, they have all uniformly failed to truly replace dead neurons in the ischemic core to facilitate long-term recovery. Remarkably, we observe robust repopulation of medium-spiny neurons within the ischemic core of juvenile mice following experimental stroke. Despite extensive neuronal...
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