Using anti-Xa level for adjusting intravenous unfractionated heparin infusion in peripartum thromboembolic disease

Enrica Tse, Rshmi Khurana, Gwen Clarke & Winnie Sia
BackgroundIntravenous unfractionated heparin infusion is often used to minimize the duration of time without anticoagulation around delivery in pregnant patients with high thrombotic risk. Activated partial thromboplastin time is commonly used to monitor and adjust heparin dose. However, using activated partial thromboplastin time is problematic in pregnancy because activated partial thromboplastin time response to unfractionated heparin is attenuated due to elevated Factor VIII levels and may lead to incorrect dosing.CaseWe report a case of deep...
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