Synthesis and biocompatibility assessment of polyaniline nanomaterials

Yumei Zhang, Miaomiao Zhou, Chengfu Dou, Guodong Ma, Yin Wang, Ningchuan Feng, Wenping Wang & Lanyun Fang
To investigate the biocompatibility of polyaniline nanomaterials as the drug carrier, polyaniline nanospheres with high-molecular weight (Mw ~48,000) and nanofibers with low-molecular weight (Mw ~4000) were prepared and cytotoxicity, acute oral toxicity test, and histopathology examination were performed. Cytotoxicity test showed that both nanofibers and nanospheres were quite toxic to BV2 microglia cells at higher concentration and the former were more toxic than the latter. No clear sign of acute toxicity was found after oral...
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