Hypoactivity in the Paraterminal Gyrus Following Bilateral Anterior Capsulotomy

Trevor A. Hurwitz, Christopher R. Honey, Kevin R. McLeod, Anujan Poologaindran & Annie J. Kuan
Objective:Bilateral anterior capsulotomy (BAC) is one of the ablative neurosurgical procedures used to treat major depressive disorder or obsessive-compulsive disorder when all other therapies fail. Tristolysis, a reduction in sadness, is the most striking clinical effect of BAC and is seen in the first 1 to 2 weeks after surgery. This retrospective study measured regional cerebral blood flow (rCBF) following surgery to identify which cortical regions were impacted and could account for this clinical effect.Methods:All...
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