Similarity and diversity of spontaneous brain activity in functional dyspepsia subtypes

Rongfeng Qi, Zhao Shi, Yifei Weng, Yulin Yang, Yifei Zhou, Wesley Surento, Guang Ming Lu, Fangyu Wang, Long Jiang Zhang & Chang Liu
BackgroundFunctional dyspepsia (FD) subtypes may differ in terms of pathophysiology, but the underlying mechanisms remain poorly understood.PurposeTo explore spontaneous brain activity in two main FD subtypes, namely epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS), using the amplitude of low-frequency fluctuation (ALFF).Material and MethodsThirty-one FD patients (18 EPS and 13 PDS) and 22 matched healthy controls (HC) underwent resting-state functional MRI scanning. Spontaneous brain activity was evaluated by measuring the ALFF and then compared...
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