Semi-quantitative cerebral blood flow parameters derived from non-invasive [15O]H2O PET studies

Thomas Koopman, Maqsood Yaqub, Dennis FR Heijtel, Aart J Nederveen, Bart NM Van Berckel, Adriaan A Lammertsma & Ronald Boellaard
Quantification of regional cerebral blood flow (CBF) using [15O]H2O positron emission tomography (PET) requires the use of an arterial input function. Arterial sampling, however, is not always possible, for example in ill-conditioned or paediatric patients. Therefore, it is of interest to explore the use of non-invasive methods for the quantification of CBF. For validation of non-invasive methods, test–retest normal and hypercapnia data from 15 healthy volunteers were used. For each subject, the data consisted of...
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