Timing of renal replacement therapy for patients with acute kidney injury: A systematic review and meta-analysis

Mark Andonovic, Richard Shemilt, Malcolm Sim, Jamie P Traynor, Martin Shaw, Patrick B Mark & Kathryn A Puxty
BackgroundAcute kidney injury is associated with high mortality, and the optimal time to start renal replacement therapy for acute kidney injury is unknown despite several randomised controlled trials on the subject. We performed a systematic review and meta-analysis to assess the effect of earlier initiation of renal replacement therapy for acute kidney injury on mortality and reported secondary outcomes.MethodsAll literature in databases EMBASE, MEDLINE and CENTRAL was searched from January 1970 to March 2019 using...
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