Continuous Light Does Not Affect Atherosclerosis in APOE*3-Leiden.CETP Mice

Maaike Schilperoort, Rosa Van Den Berg, Claudia P. Coomans, , , Sanne Boekestijn, , Jimmy F. P. Berbée, Johanna H. Meijer, Nienke R. Biermasz, Patrick C. N. Rensen & Sander Kooijman
Artificial light exposure is associated with dyslipidemia in humans, which is a major risk factor for the development of atherosclerotic cardiovascular disease. However, it remains unclear whether artificial light at night can exacerbate atherosclerosis. In this study, we exposed female APOE*3-Leiden.CETP mice, a well-established model for human-like lipid metabolism and atherosclerosis, to either a regular light-dark cycle or to constant bright light for 14 weeks. Mice exposed to constant light demonstrated a minor reduction in...
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