Etomidate, Adrenal Insufficiency and Mortality Associated With Severity of Illness: A Meta-Analysis

Stewart G. Albert & Sujata Sitaula
Purpose:Etomidate causes adrenal insufficiency. Yet in critically ill patients, it is controversial whether it increases mortality rates above that of comparator anesthetic induction agents. We postulated that etomidate would increase relative mortality rates correspondingly to the severity of illness as defined by SAPS or APACHE scores.Materials and Methods:A literature search was performed on Pub Med, SCOPUS, and Cochrane Reviews for human studies, regardless of language, between 1983 and February 2020. The search strategy used keywords,...
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