Interpreting Breast Cancer Mortality Trends Related to Introduction of Mammography Screening: A Simulation Study

Torunn Heggland, Lars Johan Vatten, Signe Opdahl & Harald Weedon-Fekjær
Background. Several studies have evaluated the effect of mammography screening on breast cancer mortality based on overall breast cancer mortality trends, with varied conclusions. The statistical power of such trend analyses is, however, not carefully studied. Methods. We estimated how the effect of screening on overall breast cancer mortality is likely to unfold. Because a screening effect is based on earlier treatment, screening can affect only new incident cases after screening introduction. To evaluate the...
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