Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals

Fiona Heeman, Denise Visser, Maqsood Yaqub, Sander Verfaillie, Tessa Timmers, Yolande AL Pijnenburg, Wiesje M van der Flier, Bart NM van Berckel, Ronald Boellaard, Adriaan A Lammertsma & Sandeep SV Golla
Alzheimer’s disease is characterized by regional reductions in cerebral blood flow (CBF). Although the gold standard for measuring CBF is [15O]H2O PET, proxies of relative CBF, derived from the early distribution phase of amyloid and tau tracers, have gained attention. The present study assessed precision of [15O]H2O derived relative and absolute CBF, and compared precision of these measures with that of (relative) CBF proxies. Dynamic [15O]H2O, [18F]florbetapir and [18F]flortaucipir PET test-retest (TrT) datasets with eleven,...
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