Therapeutic Efficacy of Human Mesenchymal Stem Cells With Different Delivery Route and Dosages in Rat Models of Spinal Cord Injury

Guangyang Liu, Zhiling Zhao, Herui Wang, Chunhua Hao, Weiting Wang, Chenliang Zhang, Tiehua Wang, Xin Li, Jingjing Xi, Shaoyun Li, Haomiao Long, Yi Mi, Li Miao, Yaoyao Chen, Liqiang Xu, Libo Zheng, Hao Wang, Ning Ding, Fengmei Zhu, Qinggang Ge & Yongjun Liu
Recent studies have shown that the use of mesenchymal stem/stromal cells (MSCs) may be a promising strategy for treating spinal cord injury (SCI). This study aimed to explore the effectiveness of human umbilical cord-derived MSCs (hUC-MSCs) with different administration routes and dosages on SCI rats. Following T10-spinal cord contusion in Sprague-Dawley rats (N = 60), three different dosages of hUC-MSCs were intrathecally injected into rats (SCI-ITH) after 24 h. Intravenous injection of hUC-MSCs (SCI-i.v.) and...
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