CCK regulates osteogenic differentiation through TNFα/NF-κB in peri-implantitis

LongHang Chou, YaTing Chang, KaiWen Lan, Meng Liu, YuKun Lu, XiaoLei Li, PeiRu Li & Yue Xu
ObjectivePeri-implantitis is characterized by peri-implant mucositis and alveolar bone resorption. This study investigated cholecystokinin (CCK) expression and the mechanism underlying its involvement in peri-implantitis.MethodsmRNA sequencing was performed using the Gene Expression Omnibus database GSE106090. Human bone marrow mesenchymal stem cells (hBMSCs) were pretreated with various concentrations of CCK (0, 10, 30, or 100 nM) for 1 hour before induction in osteogenic differentiation medium for 2 weeks. Alkaline phosphatase (ALP) activity was determined, and the cells...
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