A phase III, multi-arm multi-stage covariate-adjusted response-adaptive randomized trial to determine optimal early mobility training after stroke (AVERT DOSE)

Julie Bernhardt, Leonid Churilov, Helen Dewey, Geoffrey Donnan, Fiona Ellery, Coralie English, Lan Gao, Kathryn Hayward, Frances Horgan, Bent Indredavik, Hannah Johns, Peter Langhorne, Richard Lindley, Sheila Martins, Md Ali Katijjahbe, Sandy Middleton, Marj Moodie, Jeyaraj Pandian, Brooke Parsons, Thompson Robinson, Velandai Srikanth & Vincent Thijs
Rationale:The evidence base for acute post-stroke rehabilitation is inadequate and global guideline recommendations vary.Aim:To define optimal early mobility intervention regimens for ischemic stroke patients of mild and moderate severity.Hypotheses:Compared with a prespecified reference arm, the optimal dose regimen(s) will result in more participants experiencing little or no disability (mRS 0–2) at 3 months post-stroke (primary), fewer deaths at 3 months, fewer and less severe complications during the intervention period, faster recovery of unassisted walking, and...
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