Rapid desensitization through immunoadsorption during cardiopulmonary bypass. A novel method to facilitate human leukocyte antigen incompatible heart transplantation

Richard W Issitt, Eamonn Cudworth, Mario Cortina-Borja, Arun Gupta, Delordson Kallon, Richard Crook, Michael Shaw, Alex Robertson, Victor T Tsang, Sophie Henwood, Vivek Muthurangu, Neil J Sebire, Michael Burch & Matthew Fenton
BackgroundAnti-human leukocyte antigen (HLA)-antibody production represents a major barrier to heart transplantation, limiting recipient compatibility with potential donors and increasing the risk of complications with poor waiting-list outcomes. Currently there is no consensus to when desensitization should take place, and through what mechanism, meaning that sensitized patients must wait for a compatible donor for many months, if not years. We aimed to determine if intraoperative immunoadsorption could provide a potential desensitization methodology.MethodsAnti-HLA antibody-containing whole blood...
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