Feasibility, Acceptability, and Safety of Faecal Microbiota Transplantation in the Treatment of Major Depressive Disorder: A Pilot Randomized Controlled Trial

Jessica Emily Green, Michael Berk, Mohammadreza Mohebbi, Amy Loughman, Amelia J. McGuinness, David Castle, Mary Lou Chatterton, Joahna Perez, Philip Strandwitz, Eugene Athan, Christopher Hair, Andrew A. Nierenberg, John F. Cryan & Felice Jacka
ObjectivesPerturbations of the intestinal microbiota have been associated with mental health disorders, including major depressive disorder (MDD). Therefore, faecal microbiota transplantation (FMT) holds promise as a microbiota-modulating treatment for MDD. Yet, to date, there are no published controlled studies evaluating the use of FMT for MDD. This study aimed to address this gap by evaluating the feasibility, acceptability, and safety of FMT for MDD.MethodsThe study was an 8-week, double-blind, 2:1 parallel group, randomized controlled pilot...
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