Supplementary material. Autologous iPSC-derived four-organ-chip – KeyGene counts

Anja Ramme, Leopold Koenig, Tobias Hasenberg, Christine Schwenk, Corinna Magauer, Daniel Faust, Alexandra Lorenz, Anna Krebs, Christopher Drewell, Kerstin Schirrmann, Alexandra Grabovica, Grace Lin, Stephan Pabinger, Winfried Neuhaus, Frederic Bois, Roland Lauster, Uwe Marx & Eva-Maria Dehne
Supplementary material. Autologous iPSC-derived four-organ-chip – KeyGene counts
Microphysiological systems play a pivotal role in progressing towards a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents. All four organ models were pre-differentiated from induced pluripotent stem cells from the same healthy donor and integrated into the microphysiological system. The co-culture of the four autologous tissue models in one common medium deprived of tissue specific...
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