Celastrol-based nanomedicine hydrogels eliminate posterior capsule opacification - Supplementary table

Ying Zhang, Ruixing Liu, Chengcheng Li, Liuqi Shi, Zhihua Guo, Lei Zhu, Wen Li, Jingguo Li & Zhanrong Li
Aim: To formulate an injectable thermosensitive micelle–hydrogel hybrid system loaded with celastrol (celastrol-loaded micelle hydrogel: CMG) to prevent posterior capsule opacification (PCO). Materials & methods: Celastrol-loaded micelles were embedded in a thermosensitive hydrogel matrix to enable controlled on-demand celastrol delivery into the residual capsule. The efficacy and mechanisms of the system for eliminating PCO were evaluated in rabbits. Results: Celastrol-loaded micelles inhibited the migration and proliferation of lens epithelial cells induced by TGF-β1. Celastrol prevents...
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