Figure 2: Raptor (mTORC1) in Smooth Muscle Cells and Pulmonary Hypertension

Haiyang Tang, Kang Wu, Jian Wang, Sujana Vinjamuri, Yali Gu, Shanshan Song, Ziyi Wang, Qian Zhang, Angela Balistrieri, Ramon J. Ayon, Franz Rischard, Rebecca Vanderpool, Jiwang Chen, Guofei Zhou, Ankit A. Desai, Stephen M. Black, Joe G.N. Garcia, Jason X.-J. Yuan & Ayako Makino
SM-specific conditional and inducible KO of Raptor attenuates hypoxia-induced pulmonary hypertension in RaptorSM−/− mice. (A) Schematic strategy for the generation of RaptorSM–/– mice (a); Western blot analysis of Raptor (regulatory associated protein of mammalian target of rapamycin) in isolated PA from WT and RaptorSM−/− mice (b); and the timeline indicating the time for Tam injection (to induce Raptor KO), hypoxic exposure (to induce PH), and experimental measurements (c). (B) Representative immunofluorescence images showing cell nuclei...
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