Figure 2: In Vivo Assessment of LV Function

Dimosthenis Giamouridis, Mei Hua Gao, N. Chin Lai, Zhen Tan, Young Chul Kim, Tracy Guo, Atsushi Miyanohara, W. Matthijs Blankesteijn, Erik Biessen & H. Kirk Hammond
Eight to 10 weeks after IV delivery of AAV8.UCn2 or AAV8.UCn3 (1.9 × 1013 gc/kg) or saline, mice underwent physiological studies to assess LV function. (A and B) Peak rate of LV pressure development (A) (+dP/dt) and the slope of the end-systolic pressure-volume relationship (ESPVR) (B), a relatively load-independent measurement of LV contractility, were both increased by UCn2 and UCn3 gene transfer, with no between-group differences. (C and D) Peak rate of LV pressure decline...
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