The Burden of Post-Translational Modification (PTM)—Disrupting Mutations in the Tumor Matrisome

Elisa Holstein, Annalena Dittmann, Anni Kääriäinen, Vilma Pesola, Jarkko Koivunen, Taina Pihlajaniemi, Alexandra Naba & Valerio Izzi
BACKGROUND: To evaluate the occurrence of mutations affecting post-translational modification (PTM) sites in matrisome genes across different tumor types, in light of their genomic and functional contexts and in comparison with the rest of the genome. METHODS: This study spans 9075 tumor samples and 32 tumor types from The Cancer Genome Atlas (TCGA) Pan-Cancer cohort and identifies 151,088 non-silent mutations in the coding regions of the matrisome, of which 1811 affecting known sites of hydroxylation,...
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